Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
small molecule |
| gptkbp:approvalYear |
2020
|
| gptkbp:approvedBy |
gptkb:FDA
|
| gptkbp:ATCCode |
L01EX19
|
| gptkbp:brand |
gptkb:Ayvakit
|
| gptkbp:CASNumber |
1703793-34-3
|
| gptkbp:developer |
gptkb:Blueprint_Medicines
|
| gptkbp:hasMolecularFormula |
C26H27F2N5O
|
| gptkbp:hasSMILES |
CC1=CC2=C(C=C1)N=C(N2)N3CCN(CC3)C4=NC5=CC=CC=C5C(=C4C6=CC=CC=C6F)F
|
| https://www.w3.org/2000/01/rdf-schema#label |
avapritinib
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
gptkb:receptor_tyrosine_kinase
|
| gptkbp:molecularWeight |
463.53 g/mol
|
| gptkbp:pregnancyCategory |
not recommended
|
| gptkbp:PubChem_CID |
gptkb:CHEMBL3989989
DB15197 71665061 |
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
nausea
vomiting diarrhea edema fatigue cognitive impairment hair color changes |
| gptkbp:target |
gptkb:PDGFRA
gptkb:KIT |
| gptkbp:UNII |
6KZ7XJX9E5
|
| gptkbp:usedFor |
gptkb:gastrointestinal_stromal_tumor
gptkb:systemic_mastocytosis |
| gptkbp:bfsParent |
gptkb:KIT_D816V_mutation
gptkb:PDGFRA_gene |
| gptkbp:bfsLayer |
7
|