|
gptkbp:instanceOf
|
gptkb:small_molecule
gptkb:drug
|
|
gptkbp:approvalYear
|
2020
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
L01EX19
|
|
gptkbp:brand
|
gptkb:Ayvakit
|
|
gptkbp:CASNumber
|
1703793-34-3
|
|
gptkbp:developer
|
gptkb:Blueprint_Medicines
|
|
gptkbp:hasMolecularFormula
|
C26H27F2N5O
|
|
gptkbp:hasSMILES
|
CC1=CC2=C(C=C1)N=C(N2)N3CCN(CC3)C4=NC5=CC=CC=C5C(=C4C6=CC=CC=C6F)F
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:molecularWeight
|
463.53 g/mol
|
|
gptkbp:pregnancyCategory
|
not recommended
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL3989989
DB15197
71665061
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
diarrhea
edema
fatigue
cognitive impairment
hair color changes
|
|
gptkbp:target
|
gptkb:PDGFRA
gptkb:KIT
|
|
gptkbp:UNII
|
6KZ7XJX9E5
|
|
gptkbp:usedFor
|
gptkb:gastrointestinal_stromal_tumor
gptkb:systemic_mastocytosis
|
|
gptkbp:bfsParent
|
gptkb:PDGFRA_protein
gptkb:KIT_D816V_mutation
gptkb:KIT_gene
gptkb:Ayvakit
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
avapritinib
|