|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:PDGFRB
gptkb:beta-type_platelet-derived_growth_factor_receptor
gptkb:CD140b
gptkb:JTK12
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:idiopathic_basal_ganglia_calcification
gptkb:chronic_myelomonocytic_leukemia
gptkb:infantile_myofibromatosis
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
angiogenesis
transmembrane receptor protein tyrosine kinase activity
|
|
gptkbp:discoveredBy
|
Andersson et al.
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:EC_number
|
2.7.10.1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000113721
|
|
gptkbp:fullName
|
gptkb:Platelet-derived_growth_factor_receptor_beta
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:gene
|
gptkb:PDGFRB
|
|
gptkbp:HGNC_ID
|
8804
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGFR-beta
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:Src_family_kinases
gptkb:PLC-gamma
SH2 domain-containing proteins
|
|
gptkbp:ligand
|
gptkb:PDGF-AA
gptkb:PDGF-AB
gptkb:PDGF-BB
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5q32
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:OMIM
|
173410
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Pdgfrb
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:PDB
|
3MJG
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:structure
|
single-pass type I membrane protein
|
|
gptkbp:target
|
gptkb:dasatinib
gptkb:sorafenib
gptkb:imatinib
gptkb:pazopanib
gptkb:regorafenib
gptkb:sunitinib
gptkb:crenolanib
|
|
gptkbp:UniProtID
|
gptkb:P09619
|
|
gptkbp:bfsParent
|
gptkb:PDGFR
gptkb:PDGFRB
|
|
gptkbp:bfsLayer
|
6
|