Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:healthcare_organization
gptkb:Company gptkb:psychologist gptkb:mesenchymal_stem_cells cardiovascular diseases pulmonary hypertension fibroblasts smooth muscle cells |
| gptkbp:established |
gptkb:imatinib
gptkb:sunitinib gptkb:regorafenib |
| gptkbp:form |
PDGFR-beta isoform 1
PDGFR-beta isoform 2 |
| gptkbp:function |
receptor for platelet-derived growth factor
|
| gptkbp:has_website |
tyrosine kinase domain
fibronectin type III domain immunoglobulin-like domain |
| https://www.w3.org/2000/01/rdf-schema#label |
PDGFR-beta
|
| gptkbp:interacts_with |
SHC
MAPK PDGF P I3 K GR B2 |
| gptkbp:is_involved_in |
cell differentiation
cell proliferation immune response signal transduction inflammation wound healing cell survival tumor microenvironment extracellular matrix remodeling angiogenesis vascular remodeling tissue repair cell adhesion cell migration metastasis stem cell maintenance tissue homeostasis metabolic regulation tumor angiogenesis neovascularization tumor metastasis tumor invasion cell-cell communication cell-extracellular matrix interaction tumor microenvironment remodeling mesenchymal-epithelial transition |
| gptkbp:is_represented_in |
various tissues
|
| gptkbp:located_in |
cell membrane
|
| gptkbp:promoter |
PDGFRB
|
| gptkbp:regulates |
transforming growth factor beta (TGF-β)
PDGF-AB PDGF-BB |
| gptkbp:role |
fibrosis
atherosclerosis tumor progression |
| gptkbp:bfsParent |
gptkb:PDGFR
|
| gptkbp:bfsLayer |
6
|