|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abnormalActivityAssociatedWith
|
gptkb:cancer
autoimmune diseases
inflammatory diseases
|
|
gptkbp:composedOf
|
gptkb:Src
gptkb:Fyn
gptkb:Lyn
gptkb:Blk
gptkb:Hck
gptkb:Lck
gptkb:Yrk
Yes
Fgr
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:domain
|
kinase domain
SH2 domain
SH3 domain
|
|
gptkbp:enzymeClassification
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:function
|
signal transduction
phosphorylation of tyrosine residues
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Src family kinases
|
|
gptkbp:involvedIn
|
cell differentiation
cell survival
cell growth
immune response
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
endosomes
|
|
gptkbp:orthologIn
|
gptkb:fish
birds
amphibians
mammals
reptiles
|
|
gptkbp:postTranslationalModification
|
palmitoylation
phosphorylation
myristoylation
|
|
gptkbp:proteinFamily
|
gptkb:SRC_family
|
|
gptkbp:regulates
|
autoinhibition
phosphorylation
dephosphorylation
|
|
gptkbp:relatedTo
|
gptkb:c-Src
oncogenesis
|
|
gptkbp:target
|
gptkb:bosutinib
gptkb:dasatinib
gptkb:PP2
gptkb:saracatinib
tyrosine kinase inhibitors
|
|
gptkbp:bfsParent
|
gptkb:VEGF_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|