|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ERBB
gptkb:ERBB1
gptkb:HER1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
|
|
gptkbp:biologicalProcess
|
cell proliferation
signal transduction
receptor tyrosine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:domain
|
protein kinase domain
Furin-like cysteine-rich domain
L domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000146648
1956
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.10.1
|
|
gptkbp:fullName
|
gptkb:Epidermal_growth_factor_receptor
|
|
gptkbp:function
|
receptor for members of the epidermal growth factor family
|
|
gptkbp:gene
|
gptkb:EGFR
|
|
gptkbp:HGNC_ID
|
3236
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P15018
|
|
gptkbp:ligand
|
gptkb:amphiregulin
gptkb:betacellulin
gptkb:epiregulin
gptkb:epidermal_growth_factor
gptkb:heparin-binding_EGF-like_growth_factor
gptkb:transforming_growth_factor_alpha
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p11.2
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:glioblastoma_multiforme
gptkb:colorectal_carcinoma
gptkb:non-small_cell_lung_carcinoma
|
|
gptkbp:OMIM
|
131550
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:EGFR_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:5HG8
1M17
2GS6
2ITX
3POZ
4KRL
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
NP_005219.2
|
|
gptkbp:sequence
|
1210
|
|
gptkbp:subunit
|
homodimer
monomer
heterodimer with ERBB2
|
|
gptkbp:UniProtID
|
gptkb:P15018
|
|
gptkbp:bfsParent
|
gptkb:LIF
gptkb:leukemia_inhibitory_factor
|
|
gptkbp:bfsLayer
|
7
|