Epidermal growth factor receptor

URI: https://gptkb.org/entity/Epidermal_growth_factor_receptor
GPTKB entity
Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkb:gene
gptkbp:alternativeName gptkb:HER1
ErbB-1
gptkbp:associatedWith gptkb:non-small_cell_lung_cancer
gptkb:glioblastoma
colorectal cancer
head and neck cancer
gptkbp:biologicalProcess protein tyrosine kinase activity
gptkbp:discoveredBy gptkb:Stanley_Cohen
gptkbp:discoveredIn 1978
gptkbp:downstreamOf gptkb:MAPK_pathway
gptkb:PLCĪ³_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
gptkbp:encodedBy gptkb:EGFR_gene
gptkbp:expressedIn epithelial tissues
gptkbp:function cell signaling
regulation of cell differentiation
regulation of cell proliferation
regulation of cell growth
gptkbp:HGNC_ID 3236
https://www.w3.org/2000/01/rdf-schema#label Epidermal growth factor receptor
gptkbp:length 1210 amino acids
gptkbp:ligand gptkb:epidermal_growth_factor
gptkb:transforming_growth_factor_alpha
gptkbp:locatedIn gptkb:cell_membrane
gptkbp:locatedOnChromosome gptkb:7p11.2
gptkbp:memberOf gptkb:ErbB_family
gptkbp:molecularWeight 134 kDa
gptkbp:mutationAssociatedWith gptkb:L858R
gptkb:T790M
exon 19 deletion
exon 20 insertion
gptkbp:OMIM 131550
gptkbp:orthologIn ErbB2
ErbB3
ErbB4
gptkbp:overexpressedIn cancer progression
gptkbp:PDB 1M17
gptkbp:phosphorylates activates downstream signaling pathways
gptkbp:symbol gptkb:EGFR
gptkbp:target gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
gptkbp:UniProtID gptkb:P00533
gptkbp:bfsParent gptkb:P15056
gptkb:P42336
gptkb:P42338
gptkbp:bfsLayer 6