|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:D_factor
gptkb:HILDA
CDF
MLPLI
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
inflammatory diseases
|
|
gptkbp:discoveredBy
|
Gough et al.
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodedBy
|
gptkb:LIF_gene
|
|
gptkbp:Entrez_Gene_ID
|
3976
|
|
gptkbp:expressedIn
|
gptkb:placenta
brain
liver
bone marrow
uterus
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
gptkb:Leukemia_Inhibitory_Factor
|
|
gptkbp:function
|
regulation of cell differentiation
cytokine
maintenance of embryonic stem cell pluripotency
inhibition of differentiation in mouse embryonic stem cells
|
|
gptkbp:GO_term
|
gptkb:GO:0005126
|
|
gptkbp:HGNC_ID
|
6596
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LIF
|
|
gptkbp:locatedOnChromosome
|
gptkb:22q12.1_(human)
|
|
gptkbp:medicalUse
|
potential in infertility treatment
potential in regenerative medicine
|
|
gptkbp:molecularWeight
|
~20 kDa
|
|
gptkbp:OMIM
|
159540
|
|
gptkbp:orthologIn
|
gptkb:bovine_LIF
gptkb:mouse_LIF
gptkb:rat_LIF
|
|
gptkbp:PDB
|
gptkb:1EMR
|
|
gptkbp:recipient
|
gptkb:LIFR
gptkb:gp130
|
|
gptkbp:regulates
|
neural development
bone metabolism
inflammatory response
hematopoietic cell differentiation
|
|
gptkbp:relatedTo
|
gptkb:interleukin-6_family
|
|
gptkbp:secretes
|
gptkb:T_cells
macrophages
fibroblasts
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:UniProtID
|
gptkb:P15018
|
|
gptkbp:usedIn
|
stem cell culture
|
|
gptkbp:bfsParent
|
gptkb:CHIR99021
gptkb:Leksands_IF
gptkb:Lichtenfels
gptkb:Bad_Staffelstein
|
|
gptkbp:bfsLayer
|
6
|