|
gptkbp:instanceOf
|
gptkb:cancer
brain tumor
glioma
|
|
gptkbp:affectsOrgan
|
brain
|
|
gptkbp:firstDescribed
|
1926
|
|
gptkbp:frequency
|
about 15% of all primary brain tumors
|
|
gptkbp:grades
|
gptkb:WHO_grade_IV
|
|
gptkbp:hasBiomarker
|
gptkb:TP53_mutation
gptkb:IDH-wildtype
EGFR amplification
MGMT promoter methylation
|
|
gptkbp:hasHistopathology
|
gptkb:pseudopalisading_necrosis
microvascular proliferation
|
|
gptkbp:hasICD9Code
|
191.0
|
|
gptkbp:hasImagingFinding
|
ring-enhancing lesion on MRI
|
|
gptkbp:hasMedianSurvival
|
12-15 months
|
|
gptkbp:hasOrphanetID
|
ORPHA:705
|
|
gptkbp:hasStandardTreatment
|
gptkb:temozolomide
gptkb:tumor-treating_fields
chemotherapy
radiotherapy
surgical resection
|
|
gptkbp:hasTypicalAgeOfOnset
|
45-70 years
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
glioblastoma multiforme
|
|
gptkbp:ICD-10_code
|
C71
|
|
gptkbp:incidence
|
3.2 per 100,000 per year
|
|
gptkbp:location
|
frontal lobe
temporal lobe
cerebral hemispheres
|
|
gptkbp:MeSH_ID
|
gptkb:D005909
|
|
gptkbp:notableCase
|
gptkb:Beau_Biden
gptkb:John_McCain
gptkb:Senator_Edward_Kennedy
|
|
gptkbp:OMIM
|
137800
|
|
gptkbp:originatedIn
|
astrocyte
|
|
gptkbp:prevalence
|
most common malignant brain tumor in adults
|
|
gptkbp:prognosis
|
age
poor
MGMT promoter methylation status
extent of resection
performance status
|
|
gptkbp:riskFactor
|
radiation therapy
genetic predisposition
|
|
gptkbp:symptom
|
nausea
vomiting
headache
seizures
neurological deficit
|
|
gptkbp:synonym
|
gptkb:grade_IV_astrocytoma
GBM
|
|
gptkbp:WHOClassification
|
gptkb:CNS_WHO_grade_4
|
|
gptkbp:bfsParent
|
gptkb:glioblastoma
|
|
gptkbp:bfsLayer
|
5
|