|
gptkbp:instanceOf
|
UniProt accession number
|
|
gptkbp:alternativeName
|
gptkb:Antigen_NY-CO-13
gptkb:Phosphoprotein_p53
gptkb:Tumor_suppressor_p53
gptkb:Transformation-related_protein_53
|
|
gptkbp:associatedWith
|
gptkb:Wilms_tumor
gptkb:Melanoma
gptkb:Colorectal_cancer
gptkb:Pancreatic_cancer
gptkb:Li-Fraumeni_syndrome
gptkb:Adrenocortical_carcinoma
gptkb:Osteosarcoma
gptkb:Bladder_cancer
gptkb:Gastric_cancer
gptkb:Head_and_neck_squamous_cell_carcinoma
gptkb:Rhabdomyosarcoma
brain tumor
Lymphoma
Lung cancer
Leukemia
Prostate cancer
Esophageal cancer
Breast cancer
Hepatocellular carcinoma
Ovarian cancer
Choroid plexus papilloma
|
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gptkbp:database
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:domain
|
DNA-binding domain
Tetramerization domain
Transactivation domain
Regulatory domain
|
|
gptkbp:Entrez_Gene_ID
|
7157
ENSG00000141510
|
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gptkbp:family
|
gptkb:p53_family
|
|
gptkbp:function
|
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.
|
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gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:GO
|
gptkb:GO:0008285
GO:0005634
GO:0003677
GO:0003700
|
|
gptkbp:hasIsoform
|
12
|
|
gptkbp:HGNC_ID
|
11998
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P09874
|
|
gptkbp:KEGGID
|
gptkb:hsa:7157
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|
gptkbp:lastAnnotationUpdate
|
2022-02-23
|
|
gptkbp:latestReleaseVersion
|
1993-07-01
|
|
gptkbp:literatureReference
|
PMID: 12032546
PMID: 16413474
PMID: 20452955
PMID: 22265599
PMID: 28844662
PMID: 30778222
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:mass
|
43903 Da
|
|
gptkbp:mutationAssociatedWith
|
R282W
R175H
R248Q
R273H
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mouse_Trp53
gptkb:Zebrafish_tp53
Rat Trp53
Chicken TP53
Xenopus tp53
|
|
gptkbp:PDB
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gptkb:2OCJ
gptkb:3KMD
gptkb:4HJE
1TUP
7BWN
5XVK
6GGE
|
|
gptkbp:postTranslationalModification
|
Methylation
Phosphorylation
Acetylation
Ubiquitination
Sumoylation
Neddylation
|
|
gptkbp:protein_name
|
gptkb:Cellular_tumor_antigen_p53
|
|
gptkbp:Reactome
|
gptkb:R-HSA-69563
|
|
gptkbp:refersTo
|
Tumor protein p53 (TP53) in Homo sapiens
|
|
gptkbp:RefSeq
|
NP_000537.3
|
|
gptkbp:sequence
|
393
|
|
gptkbp:sequenceVersion
|
2
|
|
gptkbp:status
|
Reviewed
|
|
gptkbp:subcellularLocation
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gptkb:Mitochondrion
gptkb:Nucleus
gptkb:Cytoplasm
|
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gptkbp:UniGene
|
Hs.476226
|
|
gptkbp:UniProt_entry_name
|
gptkb:P53_HUMAN
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gptkbp:bfsParent
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gptkb:PARP1
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gptkbp:bfsLayer
|
7
|