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gptkbp:instanceOf
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gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:PARP
gptkb:ADPRT
gptkb:Poly(ADP-ribose)_synthetase_1
|
|
gptkbp:biologicalProcess
|
NAD+ ADP-ribosyltransferase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
gptkb:Pierre_Chambon
|
|
gptkbp:discoveredIn
|
1963
|
|
gptkbp:encodedBy
|
gptkb:PARP1_gene
|
|
gptkbp:Entrez_Gene_ID
|
142
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_2.4.2.30
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:fullName
|
gptkb:Poly_[ADP-ribose]_polymerase_1
|
|
gptkbp:function
|
DNA repair
regulation of transcription
poly(ADP-ribosyl)ation
|
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gptkbp:gene
|
gptkb:PARP1
|
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gptkbp:GO
|
gptkb:GO:0003950
|
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gptkbp:HGNC_ID
|
gptkb:HGNC:270
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PARP1
|
|
gptkbp:inhibitedBy
|
gptkb:Olaparib
gptkb:Rucaparib
gptkb:Talazoparib
gptkb:Niraparib
|
|
gptkbp:interactsWith
|
gptkb:gene
gptkb:TP53
gptkb:XRCC1
histones
|
|
gptkbp:involvedIn
|
apoptosis
cell cycle regulation
base excision repair
chromatin remodeling
single-strand break repair
|
|
gptkbp:length
|
1014 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1q42.12
|
|
gptkbp:molecularWeight
|
113 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:OMIM
|
173870
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:4UND
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
auto-poly(ADP-ribosyl)ation
|
|
gptkbp:RefSeq
|
gptkb:NP_001609.2
|
|
gptkbp:regulates
|
regulated by phosphorylation
activated by DNA damage
regulated by interaction with other proteins
|
|
gptkbp:significance
|
target for cancer therapy
|
|
gptkbp:structure
|
DNA-binding domain
automodification domain
catalytic domain
|
|
gptkbp:UniProtID
|
gptkb:P09874
|
|
gptkbp:bfsParent
|
gptkb:olaparib
gptkb:talazoparib
|
|
gptkbp:bfsLayer
|
6
|