Poly(ADP-ribose) polymerase 1

URI: https://gptkb.org/entity/Poly(ADP-ribose)_polymerase_1
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:PARP1
gptkbp:alternativeName gptkb:PARP
gptkb:ADPRT
poly(ADP-ribose) synthetase
gptkbp:associatedWith gptkb:cancer
prostate cancer
neurodegenerative diseases
gptkbp:discoveredBy gptkb:Paul_Mandel
gptkbp:discoveredIn 1963
gptkbp:domain DNA-binding domain
automodification domain
catalytic domain
gptkbp:EC_number 2.4.2.30
gptkbp:family PARP family
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:function DNA repair
cell death
poly(ADP-ribosyl)ation
regulation of chromatin structure
gptkbp:gene gptkb:PARP1
gptkbp:GO_term gptkb:GO:0003950
https://www.w3.org/2000/01/rdf-schema#label Poly(ADP-ribose) polymerase 1
gptkbp:inhibitedBy gptkb:Olaparib
gptkb:Talazoparib
gptkb:Niraparib
Veliparib
gptkbp:interactsWith gptkb:Ku70
gptkb:gene
gptkb:p53
gptkb:XRCC1
histones
gptkbp:locatedIn gptkb:nucleus
gptkbp:locatedOnChromosome human chromosome 1q42.12
gptkbp:molecularWeight 113 kDa
gptkbp:number_of_amino_acids 1014
gptkbp:OMIM 173870
gptkbp:PDB gptkb:4UND
5DS3
gptkbp:postTranslationalModification phosphorylation
acetylation
auto-poly(ADP-ribosyl)ation
gptkbp:product poly(ADP-ribose)
gptkbp:structure multi-domain protein
gptkbp:substrate NAD+
gptkbp:UniProtID gptkb:P09874
gptkbp:bfsParent gptkb:CHEMBL1201217
gptkbp:bfsLayer 7