Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:Trp53
gptkb:transformation_related_protein_53 |
| gptkbp:encodes |
gptkb:p53_protein
|
| gptkbp:Entrez_Gene_ID |
22059
ENSMUSG00000059552 |
| gptkbp:expressedIn |
various tissues
|
| gptkbp:function |
tumor suppressor
|
| https://www.w3.org/2000/01/rdf-schema#label |
Mouse Trp53
|
| gptkbp:interactsWith |
gptkb:BAX
gptkb:PUMA gptkb:MDM2 ATM p21 (Cdkn1a) |
| gptkbp:length |
390 amino acids
|
| gptkbp:locatedOnChromosome |
chromosome 11
|
| gptkbp:MGI |
MGI:98834
|
| gptkbp:mutationAssociatedWith |
increased cancer susceptibility
embryonic lethality (homozygous null) |
| gptkbp:organism |
gptkb:Mus_musculus
|
| gptkbp:orthologIn |
gptkb:human_TP53
|
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination acetylation |
| gptkbp:proteinFamily |
DNA-binding domain
oligomerization domain transactivation domain |
| gptkbp:regulates |
apoptosis
cell differentiation DNA repair metabolism cellular senescence mitochondrial function angiogenesis immune response cell cycle senescence DNA damage response autophagy oxidative stress response cell cycle arrest cellular response to stress genomic stability cellular proliferation transcription of target genes apoptotic signaling pathway stem cell self-renewal cellular quiescence |
| gptkbp:UniProtID |
gptkb:P02340
|
| gptkbp:bfsParent |
gptkb:P18146
|
| gptkbp:bfsLayer |
7
|