|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BDNF/NT-3_growth_factors_receptor
gptkb:GP145-TrkB
gptkb:TRKB
|
|
gptkbp:alternativeSplicing
|
multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:synaptic_plasticity
neurodegenerative diseases
neuronal development
|
|
gptkbp:discoveredBy
|
Lamballe et al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
gptkb:TrkB
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000148053
4915
|
|
gptkbp:expressedIn
|
brain
peripheral nervous system
|
|
gptkbp:fullName
|
gptkb:neurotrophic_receptor_tyrosine_kinase_2
|
|
gptkbp:function
|
receptor for BDNF, NT-4, and NT-3
|
|
gptkbp:HGNC_ID
|
8032
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ntrk2
|
|
gptkbp:interactsWith
|
gptkb:SHC1
gptkb:PI3K
gptkb:SRC
gptkb:PLCγ1
gptkb:GRB2
gptkb:BDNF
gptkb:NT-3
gptkb:NT-4
FYN
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
PLCγ signaling pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9_(human)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:depression
gptkb:autism_spectrum_disorder
obesity
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ntrk2
|
|
gptkbp:phosphorylates
|
Y706
Y816
Y516
Y702
Y707
|
|
gptkbp:product
|
gptkb:TrkB_receptor
|
|
gptkbp:recipient
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:target
|
cancer therapies
antidepressant drugs
|
|
gptkbp:UniProtID
|
gptkb:Q16620
|
|
gptkbp:bfsParent
|
gptkb:NTRK2
|
|
gptkbp:bfsLayer
|
7
|