|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:BDNF
gptkb:NT-3
gptkb:NT-4
|
|
gptkbp:alternativeName
|
gptkb:Neurotrophic_tyrosine_kinase_receptor_type_2
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:depression
gptkb:autism_spectrum_disorder
|
|
gptkbp:biologicalProcess
|
tyrosine kinase activity
|
|
gptkbp:discoveredBy
|
gptkb:Louis_F._Reichardt
|
|
gptkbp:downstreamOf
|
cell differentiation
neurite outgrowth
synaptic modulation
|
|
gptkbp:encodedBy
|
gptkb:NTRK2_gene
|
|
gptkbp:expressedIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:fullName
|
gptkb:Tropomyosin_receptor_kinase_B
|
|
gptkbp:function
|
receptor for brain-derived neurotrophic factor
receptor for neurotrophin-3
receptor for neurotrophin-4
|
|
gptkbp:hasIsoform
|
gptkb:TrkB-FL
gptkb:TrkB-T1
gptkb:TrkB-T2
|
|
gptkbp:HGNC_ID
|
8032
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TrkB
|
|
gptkbp:interactsWith
|
gptkb:MAPK_pathway
gptkb:PLCĪ³
gptkb:PI3K
gptkb:Shc
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
cell survival
learning
neuronal development
memory formation
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:9q21.33
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
Y515
Y706
Y816
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:target
|
antidepressant drugs
small molecule agonists
small molecule antagonists
|
|
gptkbp:UniProtID
|
gptkb:Q16620
|
|
gptkbp:bfsParent
|
gptkb:brain-derived_neurotrophic_factor
|
|
gptkbp:bfsLayer
|
6
|