|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:TrkB
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:depression
gptkb:autism_spectrum_disorder
obesity
|
|
gptkbp:biologicalProcess
|
gptkb:receptor_tyrosine_kinase
cell differentiation
nervous system development
transmembrane receptor protein tyrosine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
Lamballe et al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
gptkb:TrkB
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000148053
4915
|
|
gptkbp:expressedIn
|
brain
peripheral nervous system
|
|
gptkbp:fullName
|
gptkb:neurotrophic_receptor_tyrosine_kinase_2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasParalog
|
gptkb:NTRK1
gptkb:NTRK3
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
8032
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NTRK2
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
gptkb:neurotrophin_signaling_pathway
neuronal development
|
|
gptkbp:ligand
|
gptkb:BDNF
gptkb:NT-3
gptkb:NT-4
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9
|
|
gptkbp:mutationAssociatedWith
|
gptkb:neuroblastoma
gptkb:medulloblastoma
gptkb:glioblastoma
|
|
gptkbp:OMIM
|
600456
|
|
gptkbp:orthologInMouse
|
gptkb:Ntrk2
|
|
gptkbp:proteinFamily
|
immunoglobulin-like domain
leucine-rich repeat domain
tyrosine kinase domain
|
|
gptkbp:regulates
|
neurite outgrowth
neuronal survival
synaptic strength
|
|
gptkbp:targetOfDrug
|
gptkb:entrectinib
gptkb:larotrectinib
tropomyosin receptor kinase inhibitors
|
|
gptkbp:UniProtID
|
gptkb:Q16620
|
|
gptkbp:bfsParent
|
gptkb:chromosome_9
|
|
gptkbp:bfsLayer
|
6
|