|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:BDNF
gptkb:NT-3
gptkb:NT-4
|
|
gptkbp:alternativeName
|
gptkb:Neurotrophic_tyrosine_kinase_receptor_type_2
gptkb:Tropomyosin_receptor_kinase_B
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
psychiatric disorders
|
|
gptkbp:biologicalProcess
|
transmembrane receptor protein tyrosine kinase activity
|
|
gptkbp:domain
|
transmembrane domain
immunoglobulin-like domain
tyrosine kinase domain
|
|
gptkbp:encodedBy
|
gptkb:NTRK2_gene
|
|
gptkbp:expressedIn
|
gptkb:cancer
brain
heart
retina
peripheral nervous system
|
|
gptkbp:formsComplexWith
|
gptkb:BDNF
gptkb:NT-3
gptkb:NT-4
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
receptor for brain-derived neurotrophic factor
receptor for neurotrophin-3
receptor for neurotrophin-4
|
|
gptkbp:HGNC_ID
|
8032
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TRKB
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
neuronal development
neuronal survival
memory formation
|
|
gptkbp:locatedOnChromosome
|
gptkb:9q21.33
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:memberOf
|
receptor tyrosine kinase family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:autism_spectrum_disorder
obesity
developmental delay
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:4AT3
gptkb:1HCF
6JQH
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:regulates
|
synaptic transmission
neurite outgrowth
dendritic growth
|
|
gptkbp:target
|
antidepressant drugs
|
|
gptkbp:UniProtID
|
gptkb:Q16620
|
|
gptkbp:bfsParent
|
gptkb:Ntrk2
gptkb:NTRK2_gene
|
|
gptkbp:bfsLayer
|
8
|