|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:cleavage
|
gptkb:mature_BDNF
|
|
gptkbp:discoveredBy
|
gptkb:Yves-Alain_Barde
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:BDNF_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000176697
627
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
gptkb:cerebellum
gptkb:cortex
central nervous system
hippocampus
peripheral nervous system
amygdala
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:fullName
|
gptkb:Brain-derived_neurotrophic_factor
|
|
gptkbp:function
|
supports survival of existing neurons
important for learning and memory
involved in synaptic plasticity
encourages growth and differentiation of new neurons and synapses
|
|
gptkbp:hasPolymorphism
|
gptkb:Val66Met
|
|
gptkbp:HGNC_ID
|
HGNC:1033
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BDNF
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p14.1_(human)
|
|
gptkbp:memberOf
|
neurotrophin family
|
|
gptkbp:molecularWeight
|
~27 kDa (mature protein)
|
|
gptkbp:OMIM
|
113505
|
|
gptkbp:orthologIn
|
mouse Bdnf
rat Bdnf
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:predecessor
|
gptkb:proBDNF
|
|
gptkbp:recipient
|
gptkb:p75NTR
gptkb:TrkB
|
|
gptkbp:regulates
|
exercise increases BDNF levels
stress decreases BDNF levels
antidepressants increase BDNF expression
caloric restriction increases BDNF
cortisol decreases BDNF expression
omega-3 fatty acids increase BDNF
sleep deprivation decreases BDNF
|
|
gptkbp:relatedTo
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:depression
gptkb:Huntington's_disease
gptkb:autism_spectrum_disorder
bipolar disorder
epilepsy
schizophrenia
obesity
anxiety disorders
|
|
gptkbp:symbol
|
gptkb:BDNF
|
|
gptkbp:UniProtID
|
gptkb:P23560
|
|
gptkbp:Val66MetEffect
|
affects activity-dependent secretion of BDNF
|
|
gptkbp:bfsParent
|
gptkb:NGF
gptkb:brain-derived_neurotrophic_factor
|
|
gptkbp:bfsLayer
|
6
|