|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:activatedBy
|
ligand binding
|
|
gptkbp:alternativeName
|
gptkb:NTRK2
gptkb:BDNF/NT-3_growth_factors_receptor
gptkb:GP145-TrkB
gptkb:TrkB_tyrosine_kinase_receptor
gptkb:neurotrophic_tyrosine_kinase_receptor_type_2
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:depression
gptkb:autism_spectrum_disorder
schizophrenia
|
|
gptkbp:binds
|
gptkb:brain-derived_neurotrophic_factor
gptkb:neurotrophin-3
gptkb:neurotrophin-4
|
|
gptkbp:downstreamOf
|
gptkb:PLCĪ³_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:encodedBy
|
gptkb:NTRK2_gene
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
brain
retina
peripheral nervous system
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:function
|
regulates synaptic plasticity
regulates neuronal survival
regulates axon growth
regulates neuronal differentiation
|
|
gptkbp:hasBiologicalActivity
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:hasIsoform
|
gptkb:full-length_TrkB
gptkb:truncated_TrkB
|
|
gptkbp:HGNC_ID
|
8032
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TrkB receptor
|
|
gptkbp:involvedIn
|
synaptic transmission
neuronal plasticity
memory formation
central nervous system development
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:9q21.33
|
|
gptkbp:memberOf
|
gptkb:neurotrophic_tyrosine_kinase_receptor_family
|
|
gptkbp:modulatedBy
|
synaptic strength
neuronal connectivity
|
|
gptkbp:phosphorylates
|
autophosphorylation
|
|
gptkbp:target
|
antidepressant drugs
small molecule agonists
small molecule antagonists
|
|
gptkbp:UniProtID
|
gptkb:Q16620
|
|
gptkbp:bfsParent
|
gptkb:BDNF_gene
gptkb:neurotrophin-4
|
|
gptkbp:bfsLayer
|
7
|