|
gptkbp:instanceOf
|
immune response
lymphocyte
|
|
gptkbp:abbreviation
|
gptkb:NK
|
|
gptkbp:activatedBy
|
gptkb:interleukin-2
gptkb:interferon-beta
gptkb:interferon-alpha
gptkb:interleukin-12
|
|
gptkbp:developedBy
|
common lymphoid progenitor
|
|
gptkbp:discoveredBy
|
gptkb:Rolf_Kiessling
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:expressedIn
|
gptkb:FcγRIII_(CD16)
|
|
gptkbp:foundIn
|
lymph nodes
spleen
bone marrow
peripheral blood
|
|
gptkbp:fullName
|
gptkb:natural_killer_cells
|
|
gptkbp:function
|
cytotoxicity
immune surveillance
killing tumor cells
killing virus-infected cells
|
|
gptkbp:hasNo
|
gptkb:T_cell_receptor_(TCR)
surface immunoglobulin
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NK cells
|
|
gptkbp:inhibitedBy
|
gptkb:MHC_class_I_molecules
|
|
gptkbp:lifespan
|
about 2 weeks
|
|
gptkbp:marking
|
gptkb:CD56
CD16
lack CD3
|
|
gptkbp:mechanismOfAction
|
gptkb:antibody-dependent_cellular_cytotoxicity_(ADCC)
|
|
gptkbp:medicalUse
|
gptkb:cancer
immunotherapy
|
|
gptkbp:origin
|
bone marrow
|
|
gptkbp:partOf
|
innate immune system
|
|
gptkbp:proliferationInducedBy
|
gptkb:IL-15
gptkb:IL-2
|
|
gptkbp:recipient
|
gptkb:NKG2D
gptkb:KIR_(killer-cell_immunoglobulin-like_receptor)
gptkb:CD94/NKG2
|
|
gptkbp:recognizedBy
|
cells with low MHC I
|
|
gptkbp:relatedTo
|
gptkb:B_cells
gptkb:T_cells
|
|
gptkbp:releaseYear
|
gptkb:interferon-gamma
gptkb:granzymes
gptkb:perforin
cytokines
|
|
gptkbp:role
|
immunotherapy
autoimmune diseases
transplant rejection
viral infection response
|
|
gptkbp:subspecies
|
gptkb:CD56bright_NK_cells
gptkb:CD56dim_NK_cells
|
|
gptkbp:bfsParent
|
gptkb:CD19
|
|
gptkbp:bfsLayer
|
6
|