|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:HLA_class_I_molecules
gptkb:MHC_I
gptkb:major_histocompatibility_complex_class_I
|
|
gptkbp:associatedWith
|
immune evasion
HLA typing
graft rejection
|
|
gptkbp:compatibleWith
|
red blood cells
|
|
gptkbp:component
|
gptkb:beta-2_microglobulin
alpha chain
|
|
gptkbp:degradedBy
|
gptkb:proteasome
|
|
gptkbp:discoveredBy
|
gptkb:Jean_Dausset
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:encodedBy
|
gptkb:MHC_class_I_genes
|
|
gptkbp:foundIn
|
all nucleated cells
|
|
gptkbp:function
|
present endogenous peptides
|
|
gptkbp:gene
|
gptkb:HLA-A
gptkb:HLA-B
gptkb:HLA-C
gptkb:HLA-E
gptkb:HLA-F
gptkb:HLA-G
|
|
gptkbp:hasPolymorphism
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MHC class I molecules
|
|
gptkbp:humanForm
|
gptkb:HLA_class_I
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6_(human)
|
|
gptkbp:location
|
cell surface
|
|
gptkbp:mouseForm
|
gptkb:H-2_class_I
|
|
gptkbp:peptideLength
|
8-10 amino acids
|
|
gptkbp:peptideLoading
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:peptideSource
|
cytosolic proteins
|
|
gptkbp:presentAntigenTo
|
gptkb:CD8+_T_cells
|
|
gptkbp:recognizedBy
|
gptkb:NK_cell_receptors
cell surface receptor
|
|
gptkbp:requires
|
self/non-self discrimination
|
|
gptkbp:role
|
autoimmunity
immune surveillance
transplant rejection
tumor immunity
viral immunity
|
|
gptkbp:significance
|
organ transplantation
immunotherapy
disease susceptibility
|
|
gptkbp:species
|
vertebrates
|
|
gptkbp:structure
|
heterodimer
|
|
gptkbp:transportation
|
gptkb:TAP_transporter
|
|
gptkbp:bfsParent
|
gptkb:major_histocompatibility_complex_(MHC)
gptkb:CD8
|
|
gptkbp:bfsLayer
|
6
|