|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:alias
|
gptkb:T_cell_growth_factor
Aldesleukin (recombinant form)
TCGF
|
|
gptkbp:approvalYear
|
1992
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:binds
|
IL-2Rα (CD25)
IL-2Rβ (CD122)
IL-2Rγ (CD132)
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:encodedBy
|
gptkb:IL2_gene
|
|
gptkbp:Entrez_Gene_ID
|
3558
ENSG00000109471
|
|
gptkbp:expressedIn
|
lymphoid tissues
|
|
gptkbp:fullName
|
gptkb:Interleukin-2
|
|
gptkbp:function
|
stimulates growth of T cells
enhances NK cell activity
promotes differentiation of T cells
supports B cell proliferation
|
|
gptkbp:gene
|
gptkb:IL2
|
|
gptkbp:GO
|
gptkb:GO:0005125
|
|
gptkbp:halfLife
|
7-10 minutes
|
|
gptkbp:HGNC_ID
|
6001
|
|
gptkbp:homology
|
member of common gamma chain cytokine family
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL-2
|
|
gptkbp:inducedBy
|
gptkb:regulatory_T_cells
activation-induced cell death
|
|
gptkbp:involvedIn
|
immunotherapy
autoimmunity
|
|
gptkbp:locatedOnChromosome
|
gptkb:4q27
|
|
gptkbp:molecularWeight
|
15.5 kDa
|
|
gptkbp:OMIM
|
147680
|
|
gptkbp:PDB
|
gptkb:1M47
|
|
gptkbp:producedBy
|
activated T cells
|
|
gptkbp:promotion
|
gptkb:NK_cells
cytotoxic T lymphocytes
helper T cells
lymphokine-activated killer cells
|
|
gptkbp:recipient
|
gptkb:IL-2_receptor
|
|
gptkbp:regulates
|
immune response
immune tolerance
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
four alpha-helix bundle
|
|
gptkbp:UniProtID
|
gptkb:P60568
|
|
gptkbp:usedAsDrug
|
gptkb:aldesleukin
|
|
gptkbp:usedFor
|
metastatic melanoma
metastatic renal cell carcinoma
|
|
gptkbp:bfsParent
|
gptkb:Interleukin-2
|
|
gptkbp:bfsLayer
|
6
|