Statements (78)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:non-Hodgkin_lymphoma autoimmune diseases B-cell malignancies immunodeficiencies |
| gptkbp:breeding_range |
chromosome 16
|
| gptkbp:clinical_trial |
target for immunotherapy
biomarker for B-cell neoplasms |
| gptkbp:discovered_by |
gptkb:Dr._Charles_Janeway
|
| gptkbp:first_characterized_in |
gptkb:1980s
|
| gptkbp:function |
B-cell co-receptor
|
| https://www.w3.org/2000/01/rdf-schema#label |
CD19
|
| gptkbp:initiated_by |
B-cell receptor signaling
|
| gptkbp:interacts_with |
CD21
CD225 CD81 |
| gptkbp:involved_in |
T-cell activation
signal transduction antigen presentation immune tolerance cytokine production humoral immunity antibody production vaccine responses B-cell activation B-cell activation signaling pathways B-cell activation thresholds B-cell apoptosis B-cell development B-cell development stages B-cell differentiation pathways B-cell homeostasis B-cell lineage commitment B-cell maturation B-cell memory formation B-cell migration B-cell receptor affinity maturation B-cell receptor clustering B-cell receptor editing B-cell receptor internalization B-cell receptor signaling amplification B-cell receptor signaling attenuation B-cell receptor signaling cross-talk B-cell receptor signaling dynamics B-cell receptor signaling effects B-cell receptor signaling feedback loops B-cell receptor signaling integration B-cell receptor signaling interactions B-cell receptor signaling modulation B-cell receptor signaling networks B-cell receptor signaling outcomes B-cell receptor signaling pathways B-cell receptor signaling pathways regulation B-cell survival pathways B-cell tolerance mechanisms germinal center formation memory B-cell formation plasma cell differentiation |
| gptkbp:is_expressed_in |
B-cell lineage
malignant B cells normal B cells |
| gptkbp:is_targeted_at |
gptkb:CAR_T-cell_therapy
|
| gptkbp:location |
B cells
|
| gptkbp:orthologs |
found in many vertebrates
|
| gptkbp:promoter |
CD19 gene
|
| gptkbp:promotes |
B-cell proliferation
|
| gptkbp:role |
immune response
|
| gptkbp:targets |
monoclonal antibodies
CAR T-cell therapies |
| gptkbp:weight |
approximately 95 k Da
|
| gptkbp:bfsParent |
gptkb:Yescarta
gptkb:Kymriah gptkb:Blincyto gptkb:CAR_T-cell_therapy gptkb:B_lymphocytes gptkb:B-cell_ALL |
| gptkbp:bfsLayer |
5
|