|
gptkbp:instanceOf
|
gptkb:protein
cytokine
|
|
gptkbp:composedOf
|
p35 subunit
p40 subunit
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
gptkb:IL12A_gene
gptkb:IL12B_gene
|
|
gptkbp:foundIn
|
humans
mice
|
|
gptkbp:function
|
induces production of interferon-gamma
stimulates differentiation of naive T cells into Th1 cells
enhances cytotoxic activity of natural killer cells
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interleukin-12
|
|
gptkbp:involvedIn
|
inflammation
immune response
|
|
gptkbp:locatedOnChromosome
|
gptkb:3p12-3q13.2_(IL12A)
gptkb:5q31.1-33.1_(IL12B)
|
|
gptkbp:molecularWeight
|
70 kDa
|
|
gptkbp:OMIM
|
161560
161561
|
|
gptkbp:producedBy
|
dendritic cells
macrophages
|
|
gptkbp:recipient
|
gptkb:interleukin-12_receptor
|
|
gptkbp:relatedTo
|
gptkb:interleukin-27
gptkb:interleukin-23
|
|
gptkbp:symbol
|
gptkb:IL-12
|
|
gptkbp:target
|
gptkb:ustekinumab
gptkb:briakinumab
|
|
gptkbp:UniProtID
|
gptkb:P29459
gptkb:P29460
|
|
gptkbp:bfsParent
|
gptkb:NK_cells
gptkb:ustekinumab
gptkb:Natural_Killer_cell
gptkb:Th1_immune_response
gptkb:Th1_cells
|
|
gptkbp:bfsLayer
|
7
|