Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:cytokine
gptkb:protein |
| gptkbp:composedOf |
p35 subunit
p40 subunit |
| gptkbp:discoveredIn |
1989
|
| gptkbp:encodedBy |
gptkb:IL12A_gene
gptkb:IL12B_gene |
| gptkbp:foundIn |
humans
mice |
| gptkbp:function |
induces production of interferon-gamma
stimulates differentiation of naive T cells into Th1 cells enhances cytotoxic activity of natural killer cells |
| gptkbp:involvedIn |
gptkb:immune_response
inflammation |
| gptkbp:locatedOnChromosome |
gptkb:3p12-3q13.2_(IL12A)
gptkb:5q31.1-33.1_(IL12B) |
| gptkbp:molecularWeight |
70 kDa
|
| gptkbp:OMIM |
161560
161561 |
| gptkbp:producedBy |
dendritic cells
macrophages |
| gptkbp:recipient |
gptkb:interleukin-12_receptor
|
| gptkbp:relatedTo |
gptkb:interleukin-27
gptkb:interleukin-23 |
| gptkbp:symbol |
gptkb:IL-12
|
| gptkbp:target |
gptkb:ustekinumab
gptkb:briakinumab |
| gptkbp:UniProtID |
gptkb:P29459
gptkb:P29460 |
| gptkbp:bfsParent |
gptkb:Natural_Killer_cell
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
interleukin-12
|