|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodedBy
|
gptkb:IL15_gene
|
|
gptkbp:enemyOf
|
IL-15Rα-Fc
|
|
gptkbp:Entrez_Gene_ID
|
3600
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
gptkb:thymus
heart
liver
spleen
intestine
|
|
gptkbp:foundIn
|
humans
mice
|
|
gptkbp:fullName
|
Interleukin-15
|
|
gptkbp:function
|
promotes survival of memory CD8+ T cells
stimulates NK cell proliferation
stimulates T cell proliferation
|
|
gptkbp:gene
|
IL15
|
|
gptkbp:hasTherapeuticUse
|
immunotherapy
HIV treatment (investigational)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL-15
|
|
gptkbp:involvedIn
|
gptkb:graft-versus-host_disease
multiple sclerosis
type 1 diabetes
psoriasis
rheumatoid arthritis
celiac disease
inflammatory bowel disease
|
|
gptkbp:locatedOnChromosome
|
4q31
|
|
gptkbp:molecularWeight
|
14-15 kDa
|
|
gptkbp:OMIM
|
600554
|
|
gptkbp:orthologIn
|
gptkb:mouse_IL-15
|
|
gptkbp:PDB
|
4GS7
|
|
gptkbp:producedBy
|
dendritic cells
macrophages
fibroblasts
monocytes
epithelial cells
|
|
gptkbp:promotion
|
gptkb:NK_cells
gptkb:CD8+_T_cells
invariant NKT cells
|
|
gptkbp:receptorComponent
|
gptkb:IL-15Rα
IL-2Rβ
γc (common gamma chain)
|
|
gptkbp:recipient
|
gptkb:IL-15_receptor
|
|
gptkbp:regulates
|
cytotoxicity
apoptosis inhibition
lymphocyte homeostasis
|
|
gptkbp:relatedTo
|
gptkb:IL-2
IL-21
|
|
gptkbp:role
|
immunotherapy
inflammation
immune response
autoimmunity
|
|
gptkbp:structure
|
four-helix bundle
|
|
gptkbp:UniProtID
|
P40933
|
|
gptkbp:bfsParent
|
gptkb:NK_cells
|
|
gptkbp:bfsLayer
|
7
|