|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
CD16
|
|
gptkbp:antibodyRecognition
|
gptkb:IgG3
gptkb:IgG1
gptkb:IgG4
|
|
gptkbp:binds
|
gptkb:IgG
|
|
gptkbp:CDMarker
|
CD16
|
|
gptkbp:encodedBy
|
FCGR3A gene
FCGR3B gene
|
|
gptkbp:expressedIn
|
gptkb:eosinophils
dendritic cells
monocytes
|
|
gptkbp:foundOnCellType
|
gptkb:neutrophil
macrophage
natural killer cell
|
|
gptkbp:function
|
phagocytosis
mediates antibody-dependent cellular cytotoxicity
|
|
gptkbp:gene
|
gptkb:FCGR3A
gptkb:FCGR3B
|
|
gptkbp:hasPolymorphism
|
NA1/NA2
V158F
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FcγRIII (CD16)
|
|
gptkbp:involvedIn
|
inflammation
autoimmune disease
immune complex clearance
|
|
gptkbp:locatedOnChromosome
|
1q23
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
50-80 kDa
|
|
gptkbp:OMIM
|
146740
|
|
gptkbp:recognizedBy
|
gptkb:IgG2
|
|
gptkbp:roleInImmunity
|
innate immunity
adaptive immunity
|
|
gptkbp:significance
|
autoimmune disorders
allergic reactions
therapeutic antibody response
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:subspecies
|
FcγRIIIa
FcγRIIIb
|
|
gptkbp:target
|
gptkb:rituximab
gptkb:trastuzumab
monoclonal antibody therapy
alemtuzumab
|
|
gptkbp:UniProtID
|
O75015
P08637
|
|
gptkbp:bfsParent
|
gptkb:NK_cells
|
|
gptkbp:bfsLayer
|
7
|