Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
pore-forming protein
|
| gptkbp:associatedWith |
gptkb:familial_hemophagocytic_lymphohistiocytosis
|
| gptkbp:discoveredIn |
1985
|
| gptkbp:encodedBy |
gptkb:PRF1_gene
|
| gptkbp:foundIn |
gptkb:natural_killer_cells
cytotoxic T lymphocytes |
| gptkbp:function |
facilitates entry of granzymes
forms pores in target cell membranes |
| https://www.w3.org/2000/01/rdf-schema#label |
perforin
|
| gptkbp:locale |
cytoplasmic granules
|
| gptkbp:molecularWeight |
~67 kDa
|
| gptkbp:releaseYear |
exocytosis
|
| gptkbp:requires |
cell-mediated cytotoxicity
|
| gptkbp:role |
immune response
apoptosis induction |
| gptkbp:species |
gptkb:human
gptkb:mouse |
| gptkbp:structure |
contains C2 domain
contains MACPF domain |
| gptkbp:UniProtID |
P14222
|
| gptkbp:bfsParent |
gptkb:Killer_T_Cell
|
| gptkbp:bfsLayer |
5
|