|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:alsoKnownAs
|
gptkb:IFN-γ
|
|
gptkbp:associatedWith
|
autoimmune diseases
inflammatory diseases
|
|
gptkbp:CASNumber
|
82115-62-6
|
|
gptkbp:category
|
signaling molecules
interferons
immune system proteins
|
|
gptkbp:discoveredIn
|
1965
|
|
gptkbp:encodedBy
|
gptkb:IFNG_gene
|
|
gptkbp:function
|
immunomodulation
immune response regulation
antiviral activity
activation of macrophages
antimicrobial activity
|
|
gptkbp:GO_term
|
GO:0005132
|
|
gptkbp:halfLife
|
~5-10 hours (in humans)
|
|
gptkbp:hasApprovedDrug
|
gptkb:Actimmune
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interferon-gamma
|
|
gptkbp:inducedBy
|
expression of immunoproteasome subunits
production of nitric oxide in macrophages
|
|
gptkbp:inhibitedBy
|
cell proliferation
viral replication
|
|
gptkbp:involvedIn
|
gptkb:Th1_immune_response
|
|
gptkbp:MeSH_ID
|
D016153
|
|
gptkbp:molecularWeight
|
~17 kDa (monomer)
|
|
gptkbp:producedBy
|
gptkb:natural_killer_cells
gptkb:T_cells
|
|
gptkbp:promotion
|
antigen presentation
MHC class II expression
|
|
gptkbp:PubChem_CID
|
CHEBI:50113
|
|
gptkbp:recipient
|
gptkb:interferon-gamma_receptor
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UNII
|
K3Z4F929H6
|
|
gptkbp:usedFor
|
gptkb:chronic_granulomatous_disease
severe malignant osteopetrosis
|
|
gptkbp:bfsParent
|
gptkb:Macrophage
|
|
gptkbp:bfsLayer
|
5
|