|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:caspases
apoptosis pathways
|
|
gptkbp:alternativeName
|
cytotoxic granule proteases
lymphocyte serine proteases
|
|
gptkbp:discoveredBy
|
gptkb:Jürg_Tschopp
|
|
gptkbp:encodedBy
|
gptkb:GZMA_gene
gptkb:GZMB_gene
gptkb:GZMH_gene
gptkb:GZMK_gene
gptkb:GZMM_gene
|
|
gptkbp:firstDescribed
|
1986
|
|
gptkbp:foundIn
|
gptkb:natural_killer_cells
cytotoxic T lymphocytes
|
|
gptkbp:function
|
induce apoptosis in target cells
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
granzymes
|
|
gptkbp:inhibitedBy
|
gptkb:serpins
|
|
gptkbp:involvedIn
|
cell-mediated cytotoxicity
|
|
gptkbp:location
|
cytoplasmic granules
|
|
gptkbp:mechanismOfAction
|
serine protease activity
|
|
gptkbp:proteinFamily
|
gptkb:chymotrypsin/caspase_family
|
|
gptkbp:relatedTo
|
gptkb:perforin
|
|
gptkbp:releaseYear
|
exocytosis
|
|
gptkbp:role
|
immune response
elimination of tumor cells
elimination of virus-infected cells
|
|
gptkbp:significance
|
infectious diseases
immunotherapy
autoimmune diseases
inflammatory diseases
|
|
gptkbp:species
|
birds
mammals
reptiles
|
|
gptkbp:structure
|
serine protease domain
|
|
gptkbp:target
|
intracellular proteins
|
|
gptkbp:transportedWith
|
gptkb:perforin
|
|
gptkbp:type
|
gptkb:granzyme_A
gptkb:granzyme_B
gptkb:granzyme_H
gptkb:granzyme_K
gptkb:granzyme_M
|
|
gptkbp:bfsParent
|
gptkb:Killer_T_Cell
|
|
gptkbp:bfsLayer
|
5
|