Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
natural killer cell subtype
|
| gptkbp:alternativeName |
CD56brightCD16dim/neg NK cells
immunoregulatory NK cells |
| gptkbp:cytotoxicity |
low
|
| gptkbp:decreasedIn |
gptkb:cancer
chronic viral infections |
| gptkbp:differentiationPotential |
can differentiate into CD56dim NK cells
|
| gptkbp:expressedIn |
CD56 (NCAM1)
low levels of killer-cell immunoglobulin-like receptors (KIRs) high levels of CD94/NKG2A |
| gptkbp:expressesLow |
CD16 (FcγRIII)
|
| gptkbp:firstDescribed |
1990s
|
| gptkbp:foundIn |
gptkb:tonsils
lymph nodes spleen peripheral blood secondary lymphoid tissues |
| gptkbp:frequencyInBlood |
~10% of NK cells
|
| gptkbp:frequencyInLymphNodes |
>90% of NK cells
|
| gptkbp:function |
cytokine production
immunoregulation |
| gptkbp:hasNo |
gptkb:CD57
high levels of granzyme B high levels of perforin |
| https://www.w3.org/2000/01/rdf-schema#label |
CD56bright NK cells
|
| gptkbp:improves |
pregnancy
certain autoimmune diseases |
| gptkbp:lifeStage |
less mature than CD56dim NK cells
|
| gptkbp:marking |
gptkb:CD117_(c-Kit)
gptkb:CD62L gptkb:CD56bright gptkb:CD27 CCR7 CD16dim/negative CD94high KIRlow NKG2Ahigh |
| gptkbp:proliferationCapacity |
high
|
| gptkbp:proportionOfNKCells |
~10%
|
| gptkbp:response |
gptkb:IL-15
gptkb:IL-2 gptkb:IL-12 gptkb:IL-18 |
| gptkbp:role |
early immune response
regulation of adaptive immunity |
| gptkbp:secretes |
gptkb:TNF-alpha
gptkb:GM-CSF gptkb:IL-10 gptkb:IFN-gamma |
| gptkbp:studiedIn |
immunotherapy research
|
| gptkbp:bfsParent |
gptkb:NK_cells
|
| gptkbp:bfsLayer |
7
|