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gptkbp:instanceOf
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gptkb:natural_killer_cell_subtype
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gptkbp:alternativeName
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CD56brightCD16dim/neg NK cells
immunoregulatory NK cells
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gptkbp:cytotoxicity
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low
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gptkbp:decreasedIn
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gptkb:cancer
chronic viral infections
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gptkbp:differentiationPotential
|
can differentiate into CD56dim NK cells
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gptkbp:expressedIn
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CD56 (NCAM1)
low levels of killer-cell immunoglobulin-like receptors (KIRs)
high levels of CD94/NKG2A
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gptkbp:expressesLow
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CD16 (FcγRIII)
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gptkbp:firstDescribed
|
1990s
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gptkbp:foundIn
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gptkb:tonsils
lymph nodes
spleen
peripheral blood
secondary lymphoid tissues
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gptkbp:frequencyInBlood
|
~10% of NK cells
|
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gptkbp:frequencyInLymphNodes
|
>90% of NK cells
|
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gptkbp:function
|
cytokine production
immunoregulation
|
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gptkbp:hasNo
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gptkb:CD57
high levels of granzyme B
high levels of perforin
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gptkbp:improves
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pregnancy
certain autoimmune diseases
|
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gptkbp:lifeStage
|
less mature than CD56dim NK cells
|
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gptkbp:marking
|
gptkb:CD117_(c-Kit)
gptkb:CD62L
gptkb:CD56bright
gptkb:CD27
CCR7
CD16dim/negative
CD94high
KIRlow
NKG2Ahigh
|
|
gptkbp:proliferationCapacity
|
high
|
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gptkbp:proportionOfNKCells
|
~10%
|
|
gptkbp:response
|
gptkb:IL-15
gptkb:IL-2
gptkb:IL-12
gptkb:IL-18
|
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gptkbp:role
|
early immune response
regulation of adaptive immunity
|
|
gptkbp:secretes
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gptkb:TNF-alpha
gptkb:GM-CSF
gptkb:IL-10
gptkb:IFN-gamma
|
|
gptkbp:studiedIn
|
immunotherapy research
|
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gptkbp:bfsParent
|
gptkb:NK_cells
gptkb:natural_killer_(NK)_cells
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gptkbp:bfsLayer
|
8
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|
https://www.w3.org/2000/01/rdf-schema#label
|
CD56bright NK cells
|