|
gptkbp:instanceOf
|
white blood cell
lymphocyte
|
|
gptkbp:activatedBy
|
antigen binding
|
|
gptkbp:canBe
|
antigen-presenting cells
malignant in leukemia
malignant in lymphoma
|
|
gptkbp:cause
|
gptkb:B_cell_lymphoma
autoimmune diseases
|
|
gptkbp:deficiencyCauses
|
gptkb:agammaglobulinemia
|
|
gptkbp:developedBy
|
hematopoietic stem cells
|
|
gptkbp:differentiateInto
|
plasma cells
memory B cells
|
|
gptkbp:discoveredBy
|
gptkb:Max_Cooper
|
|
gptkbp:expressedIn
|
gptkb:MHC_class_II_molecules
B cell receptor
surface immunoglobulin
|
|
gptkbp:firstDescribed
|
1965
|
|
gptkbp:foundIn
|
bone marrow
|
|
gptkbp:function
|
mediate humoral immunity
produce antibodies
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
B cells
|
|
gptkbp:interactsWith
|
T helper cells
|
|
gptkbp:marking
|
gptkb:CD20
gptkb:CD22
gptkb:CD79a
gptkb:CD79b
gptkb:CD19
gptkb:CD21
|
|
gptkbp:maturation
|
bone marrow
|
|
gptkbp:namedAfter
|
gptkb:bursa_of_Fabricius
|
|
gptkbp:presentIn
|
gptkb:mucosa-associated_lymphoid_tissue
blood
lymph nodes
spleen
|
|
gptkbp:produces
|
immunoglobulins
|
|
gptkbp:proliferateIn
|
germinal centers
|
|
gptkbp:requires
|
interleukin-21 for differentiation
interleukin-4 for activation
vaccine response
|
|
gptkbp:role
|
gptkb:adaptive_immune_system
|
|
gptkbp:subspecies
|
follicular B cell
marginal zone B cell
memory B cell
naive B cell
plasma cell
regulatory B cell
|
|
gptkbp:target
|
gptkb:rituximab
|
|
gptkbp:undergo
|
class switch recombination
somatic hypermutation
|
|
gptkbp:bfsParent
|
gptkb:virus
|
|
gptkbp:bfsLayer
|
5
|