antibody-dependent cellular cytotoxicity (ADCC)
GPTKB entity
Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
immunological process
|
| gptkbp:abbreviation |
gptkb:ADCC
|
| gptkbp:activatedBy |
antibody binding to antigens on target cell surface
|
| gptkbp:firstDescribed |
1960s
|
| https://www.w3.org/2000/01/rdf-schema#label |
antibody-dependent cellular cytotoxicity (ADCC)
|
| gptkbp:importantFor |
immune defense against cancer cells
immune defense against parasites immune defense against viruses |
| gptkbp:involves |
antibodies
effector cells target cells |
| gptkbp:mediatedBy |
gptkb:natural_killer_cells
gptkb:eosinophils macrophages neutrophils |
| gptkbp:relatedTo |
cell-mediated cytotoxicity
complement-dependent cytotoxicity (CDC) |
| gptkbp:requires |
gptkb:Fc_receptors
|
| gptkbp:result |
lysis of target cells
|
| gptkbp:usedIn |
therapeutic monoclonal antibodies
|
| gptkbp:bfsParent |
gptkb:NK_cells
|
| gptkbp:bfsLayer |
7
|