|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:MKK4
gptkb:JNKK1
gptkb:PRKMK4
SEK1
|
|
gptkbp:associatedWith
|
gptkb:cancer
pancreatic cancer
prostate cancer
|
|
gptkbp:biologicalProcess
|
apoptosis
cell differentiation
cell proliferation
signal transduction
kinase activity
|
|
gptkbp:discoveredBy
|
independent research groups in the 1990s
|
|
gptkbp:encodes
|
gptkb:Mitogen-activated_protein_kinase_kinase_4
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000100564
6416
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
protein kinase activity
MAP kinase kinase activity
|
|
gptkbp:HGNC_ID
|
6846
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP2K4 gene
|
|
gptkbp:interactsWith
|
gptkb:TAK1
gptkb:MAP3K1
gptkb:JIP1
gptkb:MAP3K2
gptkb:MAP3K4
gptkb:DAXX
JIP2
JIP3
JIP4
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
stress-activated protein kinase signaling cascade
|
|
gptkbp:length
|
399 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
17p11.2
|
|
gptkbp:mutationAssociatedWith
|
loss of function associated with tumorigenesis
|
|
gptkbp:OMIM
|
602753
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Map2k4
|
|
gptkbp:phosphorylates
|
gptkb:MAPK9
gptkb:MAPK14
gptkb:MAPK8
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:product
|
MAP2K4 protein
|
|
gptkbp:regulates
|
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P45985
|
|
gptkbp:bfsParent
|
gptkb:MKK4
|
|
gptkbp:bfsLayer
|
7
|