|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
gptkb:IKK_complex
|
|
gptkbp:alsoKnownAs
|
gptkb:TAK1
gptkb:MAP3K7
|
|
gptkbp:associatedWith
|
gptkb:cancer
apoptosis
cell differentiation
inflammatory response
|
|
gptkbp:discoveredBy
|
Hirai et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:domain
|
protein kinase domain
TAK1-binding domain
|
|
gptkbp:encodedBy
|
MAP3K7 gene
|
|
gptkbp:Entrez_Gene_ID
|
6885
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.25
|
|
gptkbp:function
|
serine/threonine protein kinase
|
|
gptkbp:HGNC_ID
|
6859
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MEKK7
|
|
gptkbp:interactsWith
|
gptkb:SMAD6
gptkb:TRAF6
gptkb:TAB1
gptkb:TAB2
gptkb:TAB3
gptkb:TRAF2
gptkb:XIAP
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
gptkb:NF-kappaB_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
6q15
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~67 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
gptkb:MKK3
gptkb:MKK4
gptkb:MKK6
gptkb:MKK7
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
NM_145331
|
|
gptkbp:regulates
|
activated by cytokines
activated by IL-1
activated by TGF-beta
activated by TNF-alpha
inhibited by SMAD6
|
|
gptkbp:UniProtID
|
O43318
|
|
gptkbp:bfsParent
|
gptkb:TAK1
|
|
gptkbp:bfsLayer
|
7
|