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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:JNKK2
gptkb:MEK7
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gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
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gptkbp:component
|
gptkb:cytoplasm
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gptkbp:discoveredIn
|
1997
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gptkbp:encodedBy
|
gptkb:MAP2K7_gene
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gptkbp:enzymeClassification
|
gptkb:EC_2.7.12.2
|
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gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_kinase_7
|
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gptkbp:function
|
MAP kinase kinase activity
phosphorylates and activates JNK (c-Jun N-terminal kinases)
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gptkbp:gene
|
gptkb:MAP2K7
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gptkbp:GOProcess
|
stress-activated MAPK cascade
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MKK7
|
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gptkbp:interactsWith
|
gptkb:TAK1
gptkb:JNK
gptkb:MAP3K1
gptkb:JIP1
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gptkbp:locatedOnChromosome
|
gptkb:chromosome_19p13.2
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gptkbp:location
|
gptkb:cytoplasm
|
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gptkbp:molecularWeight
|
~45 kDa
|
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gptkbp:organism
|
gptkb:Homo_sapiens
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gptkbp:orthologIn
|
gptkb:mouse_Map2k7
gptkb:rat_Map2k7
|
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gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
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gptkbp:phosphorylates
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gptkb:JNK1
gptkb:JNK2
gptkb:JNK3
gptkb:Ser271
gptkb:Thr275
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gptkbp:regulates
|
activated by phosphorylation by upstream kinases such as MAP3K
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gptkbp:species
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gptkb:human
gptkb:mouse
right
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gptkbp:structure
|
contains a protein kinase domain
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gptkbp:UniProtID
|
gptkb:O14733
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gptkbp:bfsParent
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gptkb:JNK_pathway
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gptkbp:bfsLayer
|
6
|