Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
stress
cytokines free radicals antigens bacterial and viral infections |
| gptkbp:associatedWith |
gptkb:cancer
neurodegenerative diseases autoimmune diseases chronic inflammation |
| gptkbp:cause |
transcription of target genes
|
| gptkbp:database |
KEGG: hsa04064
Reactome: R-HSA-975871 |
| gptkbp:discoveredBy |
gptkb:David_Baltimore
Ranjan Sen |
| gptkbp:discoveredIn |
1986
|
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:hasComponent |
canonical pathway
non-canonical pathway |
| https://www.w3.org/2000/01/rdf-schema#label |
NF-kappaB signaling pathway
|
| gptkbp:inhibitedBy |
I-kappaB proteins
|
| gptkbp:involves |
gptkb:IKK_complex
p50 p52 RelA (p65) RelB c-Rel NF-kappaB protein complex |
| gptkbp:regulates |
apoptosis
cell proliferation inflammation immune response |
| gptkbp:bfsParent |
gptkb:EDAR
|
| gptkbp:bfsLayer |
6
|