|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CL100
gptkb:ERK_phosphatase
gptkb:HVH1
gptkb:MKP-1
|
|
gptkbp:associatedWith
|
gptkb:cancer
inflammatory diseases
|
|
gptkbp:biologicalProcess
|
phosphatase activity
response to oxidative stress
cellular response to glucocorticoid stimulus
negative regulation of MAPK cascade
|
|
gptkbp:discoveredBy
|
gptkb:Keyse_SM
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000120129
1843
GC05M172073
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
heart
liver
|
|
gptkbp:fullName
|
gptkb:Dual_specificity_protein_phosphatase_1
|
|
gptkbp:function
|
dephosphorylates MAP kinases
inactivates MAPK/ERK pathway
regulates cellular response to stress
|
|
gptkbp:HGNC_ID
|
gptkb:DUSP1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DUSP1
|
|
gptkbp:length
|
367
|
|
gptkbp:locatedOnChromosome
|
5
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
5q35.1
|
|
gptkbp:molecularWeight
|
39
|
|
gptkbp:OMIM
|
600714
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Dusp1
|
|
gptkbp:PDB
|
3F81
|
|
gptkbp:phosphatase_domain
|
present
|
|
gptkbp:proteinFamily
|
gptkb:dual_specificity_phosphatases
|
|
gptkbp:regulates
|
gptkb:MAPK1
gptkb:MAPK3
gptkb:JNK
gptkb:MAPK14
gptkb:p38_MAPK
induced by glucocorticoids
induced by oxidative stress
induced by stress
induced by growth factors
|
|
gptkbp:UniProtID
|
gptkb:P28562
|
|
gptkbp:bfsParent
|
gptkb:DUSP
|
|
gptkbp:bfsLayer
|
6
|