|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:MAP2K4
gptkb:MAP2K7
|
|
gptkbp:alsoKnownAs
|
gptkb:JNK1
gptkb:c-Jun_N-terminal_kinase_1
|
|
gptkbp:discoveredBy
|
laboratory of Roger J. Davis
|
|
gptkbp:encodes
|
gptkb:Mitogen-activated_protein_kinase_8
|
|
gptkbp:Entrez_Gene_ID
|
26419 (mouse)
5599 (human)
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_2.7.11.24
|
|
gptkbp:expressedIn
|
gptkb:testis
brain
heart
liver
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:function
|
signal transduction
regulation of apoptosis
regulation of gene expression
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6881
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Mapk8
|
|
gptkbp:inhibitedBy
|
gptkb:SP600125
gptkb:JNK-IN-8
|
|
gptkbp:interactsWith
|
gptkb:ATF2
gptkb:ELK1
gptkb:c-Jun
gptkb:MAP2K4
gptkb:MAP2K7
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
inflammatory response
stress response
|
|
gptkbp:locatedOnChromosome
|
chromosome 10 (mouse)
chromosome 10q11.22 (human)
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:JNK_subgroup
|
|
gptkbp:mutationAssociatedWith
|
altered stress response
impaired T cell function
reduced apoptosis
|
|
gptkbp:OMIM
|
602896
|
|
gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
MAPK8 (human)
Mapk8 (mouse)
|
|
gptkbp:phosphorylates
|
gptkb:ATF2
gptkb:ELK1
gptkb:c-Jun
|
|
gptkbp:UniProtID
|
gptkb:P45983
|
|
gptkbp:bfsParent
|
gptkb:MAPK8
gptkb:Mitogen-activated_protein_kinase_8
|
|
gptkbp:bfsLayer
|
7
|