c-Jun N-terminal kinase 1

URI: https://gptkb.org/entity/c-Jun_N-terminal_kinase_1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	cytokines environmental stress
gptkbp:alternativeName	gptkb:JNK1 gptkb:Mitogen-activated_protein_kinase_8
gptkbp:associatedWith	gptkb:cancer gptkb:diabetes neurodegenerative diseases inflammatory diseases
gptkbp:discoveredIn	1994
gptkbp:EC_number	2.7.11.24
gptkbp:encodedBy	gptkb:MAPK8_gene
gptkbp:Entrez_Gene_ID	5599 ENSG00000107643
gptkbp:family	gptkb:MAP_kinase_family
gptkbp:function	regulates immune response regulates apoptosis regulates cell differentiation involved in stress-activated protein kinase signaling pathway phosphorylates c-Jun
gptkbp:gene	gptkb:MAPK8
gptkbp:HGNC_ID	6881
https://www.w3.org/2000/01/rdf-schema#label	c-Jun N-terminal kinase 1
gptkbp:inhibitedBy	gptkb:SP600125
gptkbp:KEGGID	hsa:5599
gptkbp:locatedOnChromosome	gptkb:chromosome_10q11.22
gptkbp:molecularWeight	46 kDa
gptkbp:OMIM	601158
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:participatedIn	gptkb:MAPK_signaling_pathway inflammatory response apoptosis pathway
gptkbp:PDB	3ELJ
gptkbp:phosphorylates	gptkb:ATF2 gptkb:Elk-1 gptkb:c-Jun Thr183 Tyr185
gptkbp:Reactome	gptkb:R-HSA-5673001
gptkbp:RefSeq	NP_002740.1
gptkbp:structureType	serine/threonine kinase
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:UniProtID	gptkb:P45983
gptkbp:bfsParent	gptkb:P42680
gptkbp:bfsLayer	6