|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:alternativeName
|
gptkb:ERK2
gptkb:p42MAPK
MAP kinase 1
|
|
gptkbp:discoveredBy
|
Meloche S et al.
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.24
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Extracellular_signal-regulated_kinase_2
|
|
gptkbp:function
|
serine/threonine kinase
|
|
gptkbp:gene
|
gptkb:MAPK1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERK-2
|
|
gptkbp:inhibitedBy
|
gptkb:PD98059
gptkb:U0126
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:locatedOnChromosome
|
22q11.22
|
|
gptkbp:molecularWeight
|
42 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:phosphorylates
|
gptkb:ELK1
gptkb:RSK
gptkb:c-Fos
|
|
gptkbp:relatedTo
|
gptkb:MAPK3
gptkb:ERK-1
|
|
gptkbp:role
|
gptkb:cancer
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:structure
|
protein kinase domain
|
|
gptkbp:UniProtID
|
gptkb:P28482
|
|
gptkbp:bfsParent
|
gptkb:MAPK1_gene
|
|
gptkbp:bfsLayer
|
7
|