|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:MEK1
gptkb:MEK2
phosphorylation
|
|
gptkbp:alsoKnownAs
|
gptkb:ERK2
gptkb:MAPK1
|
|
gptkbp:decommissioned
|
phosphatases
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:encodedBy
|
gptkb:MAPK1_gene
|
|
gptkbp:function
|
signal transduction
regulation of cell proliferation
regulation of cell survival
regulation of differentiation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p42-ERK
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
cellular response to growth factors
cellular response to mitogens
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
chromosome 22q11.22 (human)
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
|
|
gptkbp:molecularWeight
|
42 kDa
|
|
gptkbp:phosphorylates
|
transcription factors
cytoskeletal proteins
other kinases
|
|
gptkbp:significance
|
implicated in cancer
implicated in developmental disorders
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
serine/threonine kinase
|
|
gptkbp:UniProtID
|
gptkb:P28482
|
|
gptkbp:bfsParent
|
gptkb:MAPK1_gene
|
|
gptkbp:bfsLayer
|
7
|