|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:ERK_pathway
gptkb:JNK_pathway
gptkb:NF-kappaB_pathway
|
|
gptkbp:alternativeName
|
gptkb:MAP3K1
MAP/ERK kinase kinase 1
|
|
gptkbp:discoveredBy
|
Kyriakis et al.
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:domain
|
kinase domain
RING finger domain
SWIM-type zinc finger domain
|
|
gptkbp:encodedBy
|
MAP3K1 gene
|
|
gptkbp:Entrez_Gene_ID
|
4214
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.25
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_kinase_kinase_1
|
|
gptkbp:function
|
signal transduction
serine/threonine protein kinase
|
|
gptkbp:HGNC_ID
|
6842
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MEKK1
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:TAK1
gptkb:c-Jun
gptkb:TAB1
gptkb:TRAF2
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
apoptosis
cell differentiation
immune response
stress response
|
|
gptkbp:locatedOnChromosome
|
gptkb:5q11.2
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
sex development disorders
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
3F60
|
|
gptkbp:phosphorylates
|
MAP2K1 (MEK1)
MAP2K4 (MKK4)
MAP2K7 (MKK7)
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
cell proliferation
cell survival
inflammatory response
|
|
gptkbp:UniProtID
|
gptkb:Q13233
|
|
gptkbp:bfsParent
|
gptkb:MAPKKK
gptkb:MAP3K1
gptkb:MAP_kinase_kinase_kinase
|
|
gptkbp:bfsLayer
|
7
|