Mitogen-activated protein kinase kinase kinase 1

URI: https://gptkb.org/entity/Mitogen-activated_protein_kinase_kinase_kinase_1
GPTKB entity
Statements (46)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:MEKK1
gptkb:MAPKKK1
gptkbp:associatedWith gptkb:cancer
46,XY sex reversal 3
gptkbp:biologicalProcess apoptosis
cell differentiation
cell proliferation
protein kinase activity
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:enzymeCommissionNumber 2.7.11.25
gptkbp:function signal transduction
serine/threonine protein kinase activity
gptkbp:gene gptkb:MAP3K1
gptkbp:HGNC_ID 6840
https://www.w3.org/2000/01/rdf-schema#label Mitogen-activated protein kinase kinase kinase 1
gptkbp:interactsWith gptkb:14-3-3_proteins
gptkb:JNK
gptkb:ERK
gptkb:TRAF2
gptkbp:involves gptkb:JNK_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:ERK_signaling_pathway
gptkbp:locatedOnChromosome gptkb:5q11.2
gptkbp:mutationAssociatedWith cancer susceptibility
sex development disorders
gptkbp:OMIM 600982
gptkbp:organism gptkb:Homo_sapiens
gptkbp:PDB 3DD6
gptkbp:phosphorylates gptkb:MAP2K1
gptkb:MAP2K6
gptkb:MAP2K4
gptkb:MAP2K7
gptkbp:postTranslationalModification phosphorylation
sumoylation
ubiquitination
gptkbp:RefSeq NM_005921
gptkbp:regulates apoptosis
cell migration
immune response
MAPK cascade
gptkbp:UniProtID gptkb:Q13233
gptkbp:bfsParent gptkb:MAP3K1
gptkbp:bfsLayer 7