Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
signaling molecule
|
| gptkbp:activatedBy |
cytokines
UV radiation reactive oxygen species c-Jun N-terminal kinases (JNKs) |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:diabetes neurodegenerative diseases |
| gptkbp:foundIn |
eukaryotic cells
|
| https://www.w3.org/2000/01/rdf-schema#label |
JNK cascade
|
| gptkbp:includes |
gptkb:JNK1
gptkb:JNK2 gptkb:JNK3 MAP kinase kinases (MKK4, MKK7) |
| gptkbp:involvedIn |
apoptosis
cell differentiation inflammation cellular stress response |
| gptkbp:launched |
MAP kinase kinase kinases (MAP3Ks)
|
| gptkbp:partOf |
gptkb:MAPK_signaling_pathway
|
| gptkbp:regulates |
gptkb:ATF2
gptkb:Elk-1 gptkb:c-Jun transcription factors |
| gptkbp:relatedTo |
ERK cascade
p38 MAPK cascade |
| gptkbp:bfsParent |
gptkb:MAP2K7
gptkb:ELK1_HUMAN gptkb:GO:0007259 |
| gptkbp:bfsLayer |
8
|