|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
produces two isoforms
|
|
gptkbp:associatedWith
|
gptkb:chronic_myelogenous_leukemia
gptkb:cancer
gptkb:systemic_lupus_erythematosus
autoimmune diseases
|
|
gptkbp:encodes
|
Lyn protein
|
|
gptkbp:Entrez_Gene_ID
|
4067
ENSG00000060138
|
|
gptkbp:expressedIn
|
gptkb:B_lymphocytes
hematopoietic cells
myeloid cells
|
|
gptkbp:family
|
gptkb:Src_family_kinases
|
|
gptkbp:fullName
|
Lyn proto-oncogene, Src family tyrosine kinase
|
|
gptkbp:function
|
non-receptor tyrosine kinase
|
|
gptkbp:HGNC_ID
|
6735
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LYN
|
|
gptkbp:inhibitedBy
|
gptkb:bosutinib
gptkb:dasatinib
gptkb:ponatinib
gptkb:saracatinib
|
|
gptkbp:interactsWith
|
gptkb:CBL
gptkb:PIK3R1
gptkb:BLNK
gptkb:SRC
gptkb:CD79A
gptkb:CD79B
SYK
FYN
|
|
gptkbp:involvedIn
|
gptkb:B_cell_receptor_signaling_pathway
cell proliferation
immune response
apoptosis regulation
|
|
gptkbp:locatedOnChromosome
|
8q13.1
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Lyn
|
|
gptkbp:phosphorylates
|
gptkb:PI3K
gptkb:CD22
gptkb:SHP-2
gptkb:STAT5
gptkb:FcγRIIB
gptkb:SHP-1
ITAM motifs
|
|
gptkbp:structure
|
SH2 domain
SH3 domain
tyrosine kinase domain
|
|
gptkbp:UniProtID
|
P07948
|
|
gptkbp:bfsParent
|
gptkb:PLCG2
gptkb:LFLY
gptkb:Lyon-Bron_Airport
gptkb:Lyndhurst_station
gptkb:NJ_Transit_Lyndhurst_station
gptkb:Kyrgyzstan_Airlines
|
|
gptkbp:bfsLayer
|
7
|