bosutinib

GPTKB entity

Statements (44)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:drug
gptkbp:approvalYear 2012
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
gptkbp:ATCCode L01EA12
gptkbp:brand Bosulif
gptkbp:CASNumber 380843-75-4
gptkbp:chemicalClass quinoline
gptkbp:contraindication hypersensitivity to bosutinib
gptkbp:developer gptkb:Pfizer
gptkbp:drugInteraction gptkb:proton_pump_inhibitors
CYP3A4 inhibitors
CYP3A4 inducers
gptkbp:eliminationHalfLife 22 hours
gptkbp:excretion urine
feces
gptkbp:hasMolecularFormula C26H29Cl2N5O3
gptkbp:hasSMILES CC1=CC2=C(C=C1)N=C(C=C2Cl)NC(=O)C3=CC(=C(C=C3)Cl)NC4=NC=CC(=C4)C5CCN(CC5)C(=O)C
https://www.w3.org/2000/01/rdf-schema#label bosutinib
gptkbp:KEGGID D09913
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction BCR-ABL tyrosine kinase inhibition
gptkbp:metabolism liver (CYP3A4)
gptkbp:pregnancyCategory D (US)
gptkbp:proteinBinding 94%
gptkbp:PubChem_CID DB06616
4481391
5328940
CHEMBL1077510
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
vomiting
diarrhea
elevated liver enzymes
thrombocytopenia
gptkbp:synonym SKI-606
gptkbp:target gptkb:BCR-ABL
SRC family kinases
gptkbp:UNII G9B4J8MN7N
gptkbp:usedFor gptkb:chronic_myelogenous_leukemia
gptkbp:bfsParent gptkb:BCR-ABL
gptkb:chronic_myeloid_leukemia
gptkbp:bfsLayer 6