chronic myelogenous leukemia

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:disease leukemia hematologic cancer
gptkbp:abbreviation	gptkb:CML
gptkbp:affects	white blood cells
gptkbp:alsoKnownAs	gptkb:chronic_myeloid_leukemia
gptkbp:associatedWith	gptkb:Philadelphia_chromosome
gptkbp:canProgressTo	blast crisis
gptkbp:causedBy	gptkb:BCR-ABL_fusion_gene
gptkbp:characterizedBy	overproduction of myeloid cells
gptkbp:complication	gptkb:anemia bleeding infections thrombocytopenia
gptkbp:diagnosedBy	blood test bone marrow biopsy
gptkbp:firstDescribed	1845
gptkbp:frequency	1-2 cases per 100,000 people per year
gptkbp:gender	slightly more common in males
gptkbp:geneticMarker	gptkb:t(9;22)(q34;q11)_translocation
gptkbp:hasEpidemiology	more common in adults
https://www.w3.org/2000/01/rdf-schema#label	chronic myelogenous leukemia
gptkbp:ICD-10_code	C92.1
gptkbp:incidence	rare in children
gptkbp:medianAge	around 60 years
gptkbp:namedFor	gptkb:John_Hughes_Bennett gptkb:Rudolf_Virchow
gptkbp:originatedIn	bone marrow
gptkbp:parentField	oncology hematology
gptkbp:period	accelerated phase blast phase chronic phase
gptkbp:prognosis	improved with targeted therapy
gptkbp:riskFactor	exposure to ionizing radiation
gptkbp:symptom	fatigue splenomegaly weight loss night sweats
gptkbp:treatment	gptkb:dasatinib gptkb:imatinib gptkb:nilotinib stem cell transplant tyrosine kinase inhibitors
gptkbp:bfsParent	gptkb:hydroxyurea gptkb:Brian_Boyle gptkb:Kevin_Hearn
gptkbp:bfsLayer	6