|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
SIR2-like protein 4
SIR2L4
|
|
gptkbp:amendedBy
|
metabolic processes
|
|
gptkbp:encodedBy
|
SIRT4 gene
|
|
gptkbp:Entrez_Gene_ID
|
23410
ENSG00000140873
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
pancreas
|
|
gptkbp:function
|
regulation of insulin secretion
regulation of fatty acid oxidation
ADP-ribosyltransferase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SIRT4
|
|
gptkbp:inhibitedBy
|
glutamate dehydrogenase activity
|
|
gptkbp:involvedIn
|
mitochondrial function
tumor suppression
cellular response to DNA damage
|
|
gptkbp:length
|
314
|
|
gptkbp:locatedIn
|
mitochondrion
|
|
gptkbp:locatedOnChromosome
|
12
12q24.31
|
|
gptkbp:memberOf
|
sirtuin family
|
|
gptkbp:molecularWeight
|
35 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:postTranslationalModification
|
acetylation
ADP-ribosylation
|
|
gptkbp:regulates
|
gptkb:glutamate_dehydrogenase
cell proliferation
lipid metabolism
amino acid metabolism
insulin secretion
ATP production
energy homeostasis
ammonia detoxification
oxidative metabolism
|
|
gptkbp:relatedTo
|
gptkb:cancer
gptkb:diabetes
aging
metabolism
|
|
gptkbp:subcellularLocation
|
mitochondrial matrix
|
|
gptkbp:UniProtID
|
Q9Y6E7
|
|
gptkbp:bfsParent
|
gptkb:SirT
gptkb:Histone_deacetylase
gptkb:SIR-2
|
|
gptkbp:bfsLayer
|
7
|