|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:amendedBy
|
lysine residues
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:metabolic_syndrome
neurodegenerative diseases
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:encodedBy
|
SIRT5 gene
|
|
gptkbp:Entrez_Gene_ID
|
23410
|
|
gptkbp:enzymeClassification
|
NAD-dependent protein deacylase
|
|
gptkbp:enzymeCommissionNumber
|
EC 3.5.1.-
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
heart
liver
|
|
gptkbp:function
|
deglutarylase activity
demalonylase activity
desuccinylase activity
|
|
gptkbp:gene
|
gptkb:SIRT5
|
|
gptkbp:hasIsoform
|
multiple
|
|
gptkbp:hasRefSeqID
|
NM_012241
|
|
gptkbp:hasRefSeqProtein
|
NP_036373
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:14934
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SIRT5
|
|
gptkbp:interactsWith
|
gptkb:SDHA
gptkb:GLUD1
carbamoyl phosphate synthetase 1
|
|
gptkbp:locatedIn
|
mitochondrion
|
|
gptkbp:locatedOnChromosome
|
chromosome 6p23
|
|
gptkbp:memberOf
|
sirtuin family
|
|
gptkbp:molecularWeight
|
~34 kDa
|
|
gptkbp:OMIM
|
604479
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
2B4Y
4FVT
4G1C
|
|
gptkbp:regulates
|
gptkb:urea_cycle
apoptosis
fatty acid oxidation
mitochondrial metabolism
cellular energy homeostasis
reactive oxygen species detoxification
ammonia detoxification
ketone body production
|
|
gptkbp:UniProtID
|
Q9NXA8
|
|
gptkbp:bfsParent
|
gptkb:SirT
gptkb:Histone_deacetylase
gptkb:SIR-2
|
|
gptkbp:bfsLayer
|
7
|