|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:HRAS
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
3265
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.6.5.2
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
signal transduction
regulation of cell differentiation
regulation of cell growth
|
|
gptkbp:GDPBinding
|
yes
|
|
gptkbp:GTPBinding
|
yes
|
|
gptkbp:HGNC_ID
|
5173
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
H-Ras
|
|
gptkbp:interactsWith
|
gptkb:GAPs
gptkb:PI3K
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:location
|
gptkb:chromosome_11p15.5
gptkb:Golgi_apparatus
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
gptkb:small_GTPase_family
gptkb:Ras_subfamily
|
|
gptkbp:MolecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Costello_syndrome
oncogenic
codon 12
codon 13
codon 61
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:5P21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:RefSeq
|
gptkb:NP_005334.1
|
|
gptkbp:relatedTo
|
gptkb:K-Ras
gptkb:N-Ras
|
|
gptkbp:role
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
cellular senescence
apoptosis regulation
cellular proliferation
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:Ras_protein
|
|
gptkbp:bfsLayer
|
6
|