|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:KRAS
gptkb:K-ras2
gptkb:Ki-ras
gptkb:RASK2
gptkb:c-K-ras
|
|
gptkbp:alternativeSplicing
|
gptkb:K-Ras4A
gptkb:K-Ras4B
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Weinberg
|
|
gptkbp:encodedBy
|
gptkb:KRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
3845
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:HGNC_ID
|
6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
K-Ras
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
cell signaling
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
12p12.1
|
|
gptkbp:memberOf
|
gptkb:Ras_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:G12V
gptkb:G13D
gptkb:Q61H
colorectal cancer
pancreatic cancer
G12D
|
|
gptkbp:OMIM
|
190070
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
6GJ8
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
cell survival
vesicle trafficking
cell growth
cytoskeletal organization
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:structure
|
small GTPase domain
|
|
gptkbp:target
|
gptkb:adagrasib
gptkb:sotorasib
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:KRAS2
gptkb:KRAS_protein
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
gptkb:Ras_protein
gptkb:human_KRAS
|
|
gptkbp:bfsLayer
|
6
|