|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Grb-2
gptkb:Growth_factor_receptor-bound_protein_2
gptkb:ASH_protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
signal transduction
MAPK cascade
protein binding
receptor binding
SH3/SH2 adaptor activity
enzyme binding
|
|
gptkbp:cellularComponent
|
gptkb:endosome
gptkb:plasma_membrane
cytosol
|
|
gptkbp:discoveredBy
|
Lowenstein et al.
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:domain
|
SH2 domain
SH3 domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000177885
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Growth_factor_receptor-bound_protein_2
|
|
gptkbp:function
|
adaptor protein in signal transduction
links receptor tyrosine kinases to Ras signaling pathway
|
|
gptkbp:gene
|
gptkb:GRB2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GRB2 protein
|
|
gptkbp:interactsWith
|
gptkb:BCR-ABL
gptkb:EGFR
gptkb:SOS1_protein
gptkb:c-Met
gptkb:Shc_protein
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q25
|
|
gptkbp:molecularWeight
|
~25 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Grb2
|
|
gptkbp:pathway
|
gptkb:RAS_signaling_pathway
gptkb:EGFR_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:1GRI
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:requires
|
embryonic development
cell signaling
|
|
gptkbp:sequence
|
217 amino acids
|
|
gptkbp:UniProtID
|
gptkb:P62993
|
|
gptkbp:bfsParent
|
gptkb:Ras_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|